Journal: Journal of Neurology

Article Title: Recommendations to improve imaging and analysis of brain lesion load and atrophy in longitudinal studies of multiple sclerosis

doi: 10.1007/s00415-012-6762-5

Figure Lengend Snippet: Overview of available methods for lesion and atrophy segmentation that may be installed locally. See text for details

Article Snippet: BSI http://sourceforge.net/projects/bsintegral/ , Semi- automated , Whole-brain volume change measurement from scan pair , No distinction between tissue types.

Techniques: Software, Plasmid Preparation

Journal: NeuroImage : Clinical

Article Title: Translating state-of-the-art spinal cord MRI techniques to clinical use: A systematic review of clinical studies utilizing DTI, MT, MWF, MRS, and fMRI

doi: 10.1016/j.nicl.2015.11.019

Figure Lengend Snippet: Summary of ROI-based quantitative DTI studies.

Article Snippet: ; prospective, cross-sectional , PPMS (26) vs. HCs (15) , 1.5 T; Siemens; tailored cervical PAC , • C1–C7 • 24 axial slices (contiguous) , • 2D GE ± MT pre-pulse (Gaussian, 1.5 kHz offset, 7.7 ms, 500°), FA = 20°, NEX = 2 , 250 mm 2 ; 256 × 256; 1 × 1 × 5 mm 3 ; 640/12; no; NR , MTR, histogram peak, location , Semi-automatic, whole-cord, excluding voxels with MTR < 10% , • EDSS • fMRI brain activations , • Decreased MTR: 40 vs. 46, P < 0.001 • Decreased peak height: 62 vs. 112, P < 0.001 • Decreased peak location: 35 vs. 40, P = 0.003 • MTR does not correlate with EDSS • MTR metrics correlate moderately with fMRI activation of several motor areas , High; no correlations with EDSS, utility of correlations with brain fMRI activation is unclear.

Techniques: Diagnostic Assay, Sequencing, Significance Assay, Sampling, Biomarker Discovery, Comparison, Selection

Journal: NeuroImage : Clinical

Article Title: Translating state-of-the-art spinal cord MRI techniques to clinical use: A systematic review of clinical studies utilizing DTI, MT, MWF, MRS, and fMRI

doi: 10.1016/j.nicl.2015.11.019

Figure Lengend Snippet: Summary of MT studies.

Article Snippet: ; prospective, cross-sectional , PPMS (26) vs. HCs (15) , 1.5 T; Siemens; tailored cervical PAC , • C1–C7 • 24 axial slices (contiguous) , • 2D GE ± MT pre-pulse (Gaussian, 1.5 kHz offset, 7.7 ms, 500°), FA = 20°, NEX = 2 , 250 mm 2 ; 256 × 256; 1 × 1 × 5 mm 3 ; 640/12; no; NR , MTR, histogram peak, location , Semi-automatic, whole-cord, excluding voxels with MTR < 10% , • EDSS • fMRI brain activations , • Decreased MTR: 40 vs. 46, P < 0.001 • Decreased peak height: 62 vs. 112, P < 0.001 • Decreased peak location: 35 vs. 40, P = 0.003 • MTR does not correlate with EDSS • MTR metrics correlate moderately with fMRI activation of several motor areas , High; no correlations with EDSS, utility of correlations with brain fMRI activation is unclear.

Techniques: Diagnostic Assay, Activation Assay, Isolation

Journal: NeuroImage : Clinical

Article Title: Translating state-of-the-art spinal cord MRI techniques to clinical use: A systematic review of clinical studies utilizing DTI, MT, MWF, MRS, and fMRI

doi: 10.1016/j.nicl.2015.11.019

Figure Lengend Snippet: Summary of MRS studies.

Article Snippet: ; prospective, cross-sectional , PPMS (26) vs. HCs (15) , 1.5 T; Siemens; tailored cervical PAC , • C1–C7 • 24 axial slices (contiguous) , • 2D GE ± MT pre-pulse (Gaussian, 1.5 kHz offset, 7.7 ms, 500°), FA = 20°, NEX = 2 , 250 mm 2 ; 256 × 256; 1 × 1 × 5 mm 3 ; 640/12; no; NR , MTR, histogram peak, location , Semi-automatic, whole-cord, excluding voxels with MTR < 10% , • EDSS • fMRI brain activations , • Decreased MTR: 40 vs. 46, P < 0.001 • Decreased peak height: 62 vs. 112, P < 0.001 • Decreased peak location: 35 vs. 40, P = 0.003 • MTR does not correlate with EDSS • MTR metrics correlate moderately with fMRI activation of several motor areas , High; no correlations with EDSS, utility of correlations with brain fMRI activation is unclear.

Techniques: Diagnostic Assay

Journal: NeuroImage : Clinical

Article Title: Translating state-of-the-art spinal cord MRI techniques to clinical use: A systematic review of clinical studies utilizing DTI, MT, MWF, MRS, and fMRI

doi: 10.1016/j.nicl.2015.11.019

Figure Lengend Snippet: Summary of fMRI studies.

Article Snippet: ; prospective, cross-sectional , PPMS (26) vs. HCs (15) , 1.5 T; Siemens; tailored cervical PAC , • C1–C7 • 24 axial slices (contiguous) , • 2D GE ± MT pre-pulse (Gaussian, 1.5 kHz offset, 7.7 ms, 500°), FA = 20°, NEX = 2 , 250 mm 2 ; 256 × 256; 1 × 1 × 5 mm 3 ; 640/12; no; NR , MTR, histogram peak, location , Semi-automatic, whole-cord, excluding voxels with MTR < 10% , • EDSS • fMRI brain activations , • Decreased MTR: 40 vs. 46, P < 0.001 • Decreased peak height: 62 vs. 112, P < 0.001 • Decreased peak location: 35 vs. 40, P = 0.003 • MTR does not correlate with EDSS • MTR metrics correlate moderately with fMRI activation of several motor areas , High; no correlations with EDSS, utility of correlations with brain fMRI activation is unclear.

Techniques: Blocking Assay, Activation Assay